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    CIALIS for daily use is approved to treat erectile dysfunction (ED) and the frustrating urinary symptoms of benign prostatic hyperplasia (BPH).

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    Nitrates: CIALIS is contraindicated in patients using any form of organic nitrate, either regularly and/or intermittently, as the combination could cause a sudden, unsafe drop in blood pressure.
    Hypersensitivity Reactions: CIALIS is contraindicated in patients with a known serious hypersensitivity to CIALIS or ADCIRCA (tadalafil). Hypersensitivity reactions have been reported, including Stevens-Johnson syndrome and exfoliative dermatitis.
    Guanylate Cyclase (GC) Stimulators: CIALIS is contraindicated in patients using a GC stimulator, such as riociguat.
    PDE5 inhibitors, including CIALIS, may potentiate the hypotensive effects of GC stimulators.

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    Cardiovascular: Physicians should consider the cardiovascular status of their patients, since there is a degree of cardiac risk associated with sexual activity.
    Treatments for erectile dysfunction (ED), including CIALIS, should not be used in men for whom sexual activity is inadvisable as a result of their underlying cardiovascular status.
    Patients who experience symptoms upon initiation of sexual activity should be advised to refrain from further sexual activity and seek immediate medical attention.
    Phosphodiesterase 5 (PDE5) inhibitors, including CIALIS, are mild systemic vasodilators.
    Patients with left ventricular outflow obstruction (e.
    Caution is advised when CIALIS is used as a treatment for ED in men taking alpha-blockers.
    CIALIS for once daily use provides continuous plasma tadalafil levels.
    Physicians should consider this when evaluating the potential for interactions.
    Combination with other PDE5 inhibitors : CIALIS is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension.

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